Flying vaccinator; a transgenic mosquito delivers a Leishmania vaccine via blood feeding
نویسندگان
چکیده
منابع مشابه
Production of a transgenic mosquito, as a flying syringe, to deliver protective vaccine via saliva
Genetic modification has not only been applied in bacteria but also in animals. Transgenic mice, sheep, dogs, zebra fish, flies and silkworms have appeared in laboratories, as have transgenic mosquitoes. Anopheline mosquitoes that transmit malaria have been targeted for the insertion of transgenes to reduce their ability to spread disease [1]. Some laboratories, including ours, have succeeded i...
متن کاملProgress towards a Leishmania vaccine.
Leishmaniasis is a vector-born protozoan disease. Approximately 12 million individuals are affected worldwide with an estimated annual incidence of 1.5-2 million. Two clinical manifestations are recognized, cutaneous, and visceral, both of which are common in the Middle East. In both forms, infection is chronic, with potential deformities, persistence following cure, and lifelong risk of reacti...
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Reception of odorants by two main head appendages, antennae and maxillary palps, is essential for insects' survival and reproduction. There is growing evidence in the literature suggesting that the proboscis is also an olfactory appendage and its function as an additional "antenna" has been previously proposed. We surmised that movements of the labrum toward a blood vessel might be chemically o...
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A key characteristic of overwintering dormancy (diapause) in the mosquito Culex pipiens is the switch in females from blood feeding to sugar gluttony. We present evidence demonstrating that genes encoding enzymes needed to digest a blood meal (trypsin and a chymotrypsin-like protease) are down-regulated in diapause-destined females, and that concurrently, a gene associated with the accumulation...
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The spread of blood-borne pathogens by mosquitoes relies on their taking a blood meal; if there is no bite, there is no disease transmission. Although many species of mosquitoes never take a blood meal, identifying genes that distinguish blood feeding from obligate nonbiting is hampered by the fact that these different lifestyles occur in separate, genetically incompatible species. There is, ho...
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ژورنال
عنوان ژورنال: Insect Molecular Biology
سال: 2010
ISSN: 0962-1075,1365-2583
DOI: 10.1111/j.1365-2583.2010.01000.x